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While it is illegal for a drug company to promote off label uses directly and immoral to bribe doctors into prescribing a certain drug, it was also absolutely dangerous to claim Neurontin could cure disorders that it simply couldn't. For example, Neurontin has no effect on bipolar disorder. Warner Lambert sold thousands of doctors on the idea that Neurontin should be prescribed for bipolar disorder. If it did not work, they suggested increasing the dosage. One of the drug company managers told a salesman: "I don't want to see a single patient coming off Neurontin before they've been up to at least 4,800 milligrams a day. I don't want to hear that safety crap either. It's a great drug. " An untold number of bipolar patients were taken off their FDA approved medication and prescribed Neurontin alone. Although Neurontin has few side effects, it also did nothing for their disorder, leaving these patients effectively unmedicated. Nobody knows how many lives were shattered as a result, but unmedicated bipolar disorder has a mortality rate of 55 60%. Luckily for the public and patients taking Neurontin, a Warner Lambert sales representative came forward and revealed the entire scandal.
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And there must be streets and other transportation connecting the various places. These elements of cities are patched together into a complex whole that is sometimes called the urban fabric. Streets have always formed the basic transportation grid within cities and towns. Even ancient Roman cities depended on a practical system of streets, including one way streets to lessen the numbers of traffic jams of chariots, wagons, horses, and pedestrians. From the mid 20th century to the present, the need to move easily within and around cities has led to the construction of new streets and expressways, particularly in the United States. Public transportation systems such as trains, buses, and subways are considered indispensable, but they struggle to meet the demands placed on them in many urban areas. Because of greater government support, European cities have public transportation systems that are generally superior to those in the United States. Some planners believe that advanced communications such as cell phones and portable computers could replace the need for traditional transportation networks by allowing people to work, study, and shop at home. Yet even though people have increasingly used the Internet for these activities, transportation systems seem to be busier than ever. Cities often seem to be formed of several districts patched together, and urban zoning laws which restrict the types of construction, houses, and businesses allowed in some zones of the city may reinforce the differences among these districts. Historically, most cities have had a downtown area, or Central Business District CBD, where most high rise office buildings and shops are located.
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Read all the definitions listed for your words. Copy the definitions, thinking about what notions they have in common. Look your words up in a Thesaurus. Read the entries related to your words. Are there any new words that should be added to your word list?6. Write five sentences that tell the truth about your connection to your work. If you are stuck, start by filling in the blanks below. Write a three paragraph artists statement. Keep your sentences authentic and direct. Use the present tense I am, not I was, I do, not I did. Be brave: say nice things about yourself.
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Talk number 58. 19. Q. X. Sang 2008 Protein Biomarkers of HumanBreast and Prostate Cancer Invasion and Progression at the Interface of Benignand Malignant Tumors. Invited talk atthe session 32 on Cancer Invasion and Metastasis.
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